Where you look for information is determined by what kind of question you are asking. One way of classifying your question is to ask whether you are seeking background information or foreground information.
Foreground informationanswers specific questions a clinician has regarding a specific patient. Foreground resources can be divided into primary sources such as original research articles published in journals; and secondary sources such as systematic reviews of the topic, and synopses and reviews of individual studies.
A Primary Sourceis firsthand testimony or direct evidence concerning a topic under investigation. Primary resources are generally articles that appear in peer-reviewed journals and are found primarily by searching MedLine. Secondary sourcesare summaries and analyses of the evidence derived from and based on primary sources. A secondary source is a work that appraises, interprets or analyzes. It is generally at least one step removed from the evidence. Secondary resources available on the Library's EBM Resource Pageinclude Clinical Evidence, ACP Journal Club, and Cochrane Library.
If you have a choice, you may make better use of your time by searching first in secondary resources. Provided you trust the organization producing the resource (e.g. The American College of Physicians), you can rely on their judgment regarding the critical analysis of the studies. Another benefit of some secondary resources (e.g. Clinical Evidence) is that you will be able to rely on the results of several studies instead of just the one reported in a primary report.
Background informationis sought when a learner has general clinical questions regarding a topic such as what is the disorder; what causes it; how does it present; what are some treatment options. These questions can be answered by using "background" resources such as textbooks (both in print and electronic) and narrative reviews in journals which give a general overview of the topic.