These questions bring together multiple concepts related to a specific clinical situation or research topic. They are typically divided into two categories:
Evidence-Based Medicine's Levels of Evidence Pyramid version 6s
This website examines the evidence pyramid in terms of finding appropriate foreground information.
The 6S pyramid from McMaster University has provided a conceptual framework for searching information resources for evidence-based healthcare (EBHC) and is used in medical education and clinical informatics applications. There are links ot various databases and reference collections.
Alert: If a link on any one of these pages leads you to another university’s blocked library site, don't despair!
Look for access to that named link on our own DMC Library Information Resources. Libraries generally have to pay for subscriptions and so restrict their access.
DMC Library has many of these same subscriptions
Foreground questions are best answered by evidence found at different levels of the 6S Pyramid.
Dartmouth and Yale' s Evidence-Based Medicine (EBM) Pyramid with Explanation
This is a dynamic easy-to-use Evidence Pyramid with clear explanations of each level
This version was prepared by the University of Pittsburgh Health Science Library System
Alert: If a link on any one of these pages leads you to another university’s blocked library site, don't despair!
Look for access to that named link on our own DMC Library Information Resources. Libraries generally have to pay for subscriptions and so restrict their access.
DMC Library has many of these same subscriptions
Melnyck’s and Fineout-Overholt's PICO formulation with descriptors and examples
What is a PICOT Question? (From the George Gwinnett College Library)
Rating System for the Hierarchy of Evidence to Guide Clinical Interventions.
Once you have completed your literature search to find the best evidence to answer your clinical problem, this framework is one version used to help you evaluate the strength of the presented evidence.
Level |
Explanation |
I |
Evidence from a systematic review or meta-analysis of all relevant randomized controlled trials (RCTs) |
II |
Evidence obtained from well-designed RCTs |
III |
Evidence obtained from well-designed controlled trials without randomization |
IV |
Evidence from well-designed case-control and cohort studies |
V |
Evidence from systematic reviews of descriptive and qualitative studies |
VI |
Evidence from single descriptive or qualitative studies |
VII |
Evidence from the opinion of authorities and/or reports of expert committees |
Source: Modified from Elwyn et al. (2015) and Harris et al. (2001) :From Improving healthcare quality, patient outcomes, and costs with evidence-based practice
Elwyn, G., Quinlan, C., Mulley, A., Agoritsas, T., Vandik, P. O., & Guyatt, G. (2015): Trustworthy guidelines—excellent; customized care tools—even better. BioMed Central Medicine, 13(1), 199. Modified from Guyatt, G., & Rennie, D. (2002), Users’ guides to the medical literature. Chicago, IL: American Medical Association.